Endocrine Abstracts

Introduction: X-linked adrenoleukodystrophy (X-ALD) is a rare condition presented mainly in males during childhood and early adulthood. It represents almost 10% of primary adrenal insufficiency (PAI) or Addison’s disease cases.Clinical case: A 67-year-old male was diagnosed at the age of 61 with PAI during testing for mesenteric paniculitis while admitted in Internal Medicine service. He was treated with hydrocortisone and referred to outpatient end...

Introduction:: Gender dysphoria (GD) is featured by significant difference between the individual’s expressed gender and the gender others would assign him or her, with marked distress in social and occupational functionality, according to DSM-V classification. We report the experience in the clinical evaluation and the results of hormonal therapy and sex reassignment surgery in a hospital center.Methods:: It was conducted a retrospective analysis o...

Introduction: Pheochromocytomas are adrenomedullary catecholamine-secreting tumors. These account for <0.1% of all causes of hypertension and may be related to potentially fatal hypertensive crises. Can appear as sporadic tumors or associated with familial syndromes.Malignancy occurs in 15–20% of the cases and is characterized by local invasion or distant metastasis rather than capsular invasion. Tumor recurrence has been reported with a frequen...

Introduction: Diabetic nephropathy is the main global cause of end stage renal disease. According to the annual report from the Portuguese National Diabetes Observatory, in 2013, the prevalence of diabetes mellitus (DM) in new cases of chronic kidney disease was 31.2 and 11.1% in kidney transplant patients.Aim: To characterise the population of type 2 diabetic patients admitted in diabetes and kidney transplant consult (DKTC), comparing those admitted be...

Introduction: Diabetes mellitus is a common metabolic complication after kidney transplantation, occurring with a frequency of 15–30% in the first year. However, despite the high incidence, there are described few cases of diabetic nephropathy with nodular glomerulosclerosis of the allograft.Case: Female patient, 49, with autosomal dominant familial renal poliquistose diagnosed at 17 and progression for chronic end-stage renal disease, underwent ren...

Introduction: Catecholamine-secreting tumours derived from the adrenal medulla and the nodes of the autonomic nervous system are known as pheochromocytomas or paragangliomas, respectively. Although their clinical manifestations are similar, their differentiation is important from an epidemiological and prognostic point of view and their possibility of being associated with genetic syndromes.Case report: We present a case of a 16 year old patient, with no...

Metformin has recently emerged as a potential therapeutic tool for different tumour pathologies, including prostate cancer (PCa)1, one of the leading causes of cancer-deaths in men worldwide. However, the molecular mechanisms underlying the antitumor effects of metformin in PCa are not fully elucidated. In this context, previous reports have suggested a relationship between metformin and the process of alternative splicing in some cell-types. Nevertheless, the poten...

Introduction: Cystic fibrosis (CF) is a chronic disease at risk of malnutrition. The aim of the study is to assess nutritional status of patients with CF.Methods: Descriptive study of CF patients referred for a nutritional evaluation. Data collected included lung function, pancreatic and carbohydrate metabolism (according to ADA’s diagnostic criteria), anthropometric and laboratory parameters. Results are shown as mean (S.D.).<p c...

Introduction: Cardiovascular disease is present in up to 60% of patients diagnosed of acromegaly and is responsible of the major related morbidity and mortality.Case report: A 79-year-old-woman with previous history of diabetes mellitus and hypertension was admitted for acute pulmonary edema. Transthoracic echocardiogram showed a severe left ventricular dysfunction with an ejection fraction of 20%, dilated left ventricle and left atrium with a moderate m...

Objective: To compare 2 modalities of bolus-basal insulin therapy with aspart-detemir, according to the moment of administration of detemir (DET), before the lunch or bed-time, in type 1 diabetic patients with poor metabolic control.Methods: We conducted a prospective study of 40 type 1 diabetic patients, with poor metabolic control (HbAc 7–12%), randomized to receive treatment with 1 injection of DET before the lunch or bed-time and followed-up dur...